Towards a compact and precise sample holder for macromolecular crystallography.

ABSTRACT: Most of the sample holders currently used in macromolecular crystallography offer limited storage density and poor initial crystal-positioning precision upon mounting on a goniometer. This has now become a limiting factor at high-throughput beamlines, where data collection can be performed in a matter of seconds. Furthermore, this lack of precision limits the potential benefits emerging from automated harvesting systems that could provide crystal-position information which would further enhance alignment at beamlines. This situation provided the motivation for the development of a compact and precise sample holder with corresponding pucks, handling tools and robotic transfer protocols. The development process included four main phases: design, prototype manufacture, testing with a robotic

SUBMITTER: Papp G 

PROVIDER: S-EPMC5633908 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature