Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans.

ABSTRACT: Telomere defects are thought to play a role in cardiomyopathies, but the specific cell type affected by the disease in human hearts is not yet identified. The aim of this study was to systematically evaluate the cell type specificity of telomere shortening in patients with heart failure in relation to their cardiac disease, age, and sex. We studied cardiac tissues from patients with heart failure by utilizing telomere quantitative fluorescence in situ hybridization, a highly sensitive method with single-cell resolution. In this study, total of 63 human left ventricular samples, including 37 diseased and 26 nonfailing donor hearts, were stained for telomeres in combination with cardiomyocyte- or α-smooth muscle cell-specific markers, cardiac troponin T, and smooth muscle actin, respectively

SUBMITTER: Sharifi-Sanjani M 

PROVIDER: S-EPMC5634248 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature