Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial.

ABSTRACT:

Background

In this double-blind randomized placebo-controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina.

Methods and results

Seventy patients with stable angina, positive electrocardiogram treadmill test, and either angiographic or functional test evidence of significant ischemic heart disease were randomized to receive oral treatment with either placebo or sodium nitrate (600 mg; 7 mmol) for 7 to 10 days, followed by a 2-week washout period before crossing over to the other treatment (n=34 placebo-nitrate, n=36 nitrate-placebo). At baseline and at the end of each treatment, patients underwent modified Bruce electrocardiogram treadmill test, modified Seattle

SUBMITTER: Schwarz K 

PROVIDER: S-EPMC5634294 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature