Sustaining Intravitreal Residence With L-Arginine Peptide-Conjugated Nanocarriers.

ABSTRACT:

Purpose

Intravitreal injection of antiangiogenic agents is becoming a standard treatment for neovascular retinal diseases. Sustained release of therapeutics by injecting colloidal carriers is a promising approach to reduce the injection frequency, which reduces treatment burdens and the risk of complications on patients. Such sustained release often requires carriers to have micrometer-scale dimension that, however, can potentially promote glaucoma and inflammation. Small, polycationic particles can be immobilized in vitreous through multiple cooperative ionic interactions with hyaluronic acid of the vitreous interior, but such particles are generally toxic. Here, we synthesized and examined a biocompatible dextran-based nanocarrier (<50 nm in diameter) conjugated with cationic pep

SUBMITTER: Li H 

PROVIDER: S-EPMC5634351 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature