Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene-gene interactions.

ABSTRACT: Epistasis within disease-related genes (gene-gene interactions) was determined through contingency table measures based on multifactor dimensionality reduction (MDR) using single-nucleotide polymorphisms (SNPs). Most MDR-based methods use the single contingency table measure to detect gene-gene interactions; however, some gene-gene interactions may require identification through multiple contingency table measures. In this study, a multiobjective differential evolution method (called MODEMDR) was proposed to merge the various contingency table measures based on MDR to detect significant gene-gene interactions. Two contingency table measures, namely the correct classification rate and normalized mutual information, were selected to design the fitness functions in MODEMDR. The characteristic

SUBMITTER: Yang CH 

PROVIDER: S-EPMC5634479 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature