Pleomorphic lobular carcinoma in situ of the breast: a single institution experience with clinical follow-up and centralized pathology review.

ABSTRACT:

Purpose

The natural history of pleomorphic lobular carcinoma in situ (PLCIS) remains largely unknown.

Methods

A pathology database search (1995-2012) was performed to identify patients diagnosed with an LCIS variant. Patients with synchronous breast cancer and/or no evidence of pleomorphism were excluded. Original slides were re-evaluated by three pathologists to identify a consensus cohort of PLCIS. Borderline lesions with focal atypia were classified as LCIS with pleomorphic features (LCIS-PF). Clinical data were obtained from medical records.

Results

From 233 patients, we identified 32 with an LCIS variant diagnosis and no concurrent breast cancer. Following review, 16 cases were excluded due to lack of pleomorphism. The remaining 16 were classified as PLCIS (n = 1

SUBMITTER: De Brot M 

PROVIDER: S-EPMC5634524 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature