A simulation study of outcome adaptive randomization in multi-arm clinical trials.

ABSTRACT: Randomizing patients among treatments with equal probabilities in clinical trials is the established method to obtain unbiased comparisons. In recent years, motivated by ethical considerations, many authors have proposed outcome adaptive randomization, wherein the randomization probabilities are unbalanced, based on interim data, to favor treatment arms having more favorable outcomes. While there has been substantial controversy regarding the merits and flaws of adaptive versus equal randomization, there has not yet been a systematic simulation study in the multi-arm setting. A simulation study was conducted to evaluate four different Bayesian adaptive randomization methods and compare them to equal randomization in five-arm clinical trials. All adaptive randomization methods included an i

SUBMITTER: Wathen JK 

PROVIDER: S-EPMC5634533 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature