State-dependent metabolic partitioning and energy conservation: A theoretical framework for understanding the function of sleep.

ABSTRACT: Metabolic rate reduction has been considered the mechanism by which sleep conserves energy, similar to torpor or hibernation. This mechanism of energy savings is in conflict with the known upregulation (compared to wake) of diverse functions during sleep and neglects a potential role in energy conservation for partitioning of biological operations by behavioral state. Indeed, energy savings as derived from state-dependent resource allocations have yet to be examined. A mathematical model is presented based on relative rates of energy deployment for biological processes upregulated during either wake or sleep. Using this model, energy savings from sleep-wake cycling over constant wakefulness is computed by comparing stable limit cycles for systems of differential equations. A primary object

SUBMITTER: Schmidt MH 

PROVIDER: S-EPMC5634544 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature