Effectiveness of proton pump inhibitor in unexplained chronic cough.

ABSTRACT:

Background

Current guidelines recommend that patients with unexplained chronic cough undergo empirical proton pump inhibitor (PPI) treatment, but scientific evidence for this treatment is lacking. We investigated the effectiveness and appropriate dose of PPI therapy in chronic cough.

Methods

We included 27 patients with unexplained chronic cough after excluding subjects with positive response to postnasal drip medication. Subjects were randomized to a placebo, standard, and high dose of PPI groups with blinding. The drug or placebo was administered orally for 8 weeks, and the Leicester Cough Questionnaire (LCQ) score and visual analogue scale (VAS) scores were collected.

Results

The LCQ score in the PPI group significantly improved from 0 weeks (11.4 ± 1.4) to 4 weeks

SUBMITTER: Park HJ 

PROVIDER: S-EPMC5634560 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature