Nonlinear temporal dynamics of cerebral small vessel disease: The RUN DMC study.

ABSTRACT:

Objective

To investigate the temporal dynamics of cerebral small vessel disease (SVD) by 3 consecutive assessments over a period of 9 years, distinguishing progression from regression.

Methods

Changes in SVD markers of 276 participants of the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Imaging Cohort (RUN DMC) cohort were assessed at 3 time points over 9 years. We assessed white matter hyperintensities (WMH) volume by semiautomatic segmentation and rated lacunes and microbleeds manually. We categorized baseline WMH severity as mild, moderate, or severe according to the modified Fazekas scale. We performed mixed-effects regression analysis including a quadratic term for increasing age.

Results

Mean WMH progression over 9 years was 4.7 mL (0.54 m

SUBMITTER: van Leijsen EMC 

PROVIDER: S-EPMC5634663 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature