Vincristine, Ifosfamide, and Doxorubicin for Initial Treatment of Ewing Sarcoma in Adults.

ABSTRACT:

Background

There are no clinical trials specifically addressing chemotherapy for adults with Ewing sarcoma (ES). Five-year event-free survival (EFS) of adults on pediatric studies of ES (44%-47%) is worse than that of children treated with the same therapy (69%). The object of this study was to review the results of therapy with vincristine, ifosfamide, and doxorubicin (VID) in the multidisciplinary treatment of adults with ES at our institution.

Materials and methods

Charts for adults treated for ES from 1995 to 2011 were retrospectively reviewed. Clinician-reported radiographic tumor response, type of local therapy, pathologic response, and survival data were collected.

Results

Seventy-one patients were identified who received VID as initial therapy. The median age

SUBMITTER: Wagner MJ 

PROVIDER: S-EPMC5634776 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature