Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts.

ABSTRACT:

Background

Malignant melanoma of the skin can metastasize through blood vessels and lymphatics. The primary tumor develops a vascular microenvironment characterized by abnormal blood vessels and lymphatics and a physicochemical microenvironment characterized by low oxygen tension, regions with hypoxic tissue, and high interstitial fluid pressure (IFP). This study aimed at identifying relationships between the metastatic route of melanomas and characteristic features of the microvascular and physicochemical microenvironments of the primary tumor.

Methods

Two patient-derived xenograft (PDX) models (E-13, N-15) and four cell line-derived xenografts (CDX) models (C-10, D-12, R-18, T-22) of human melanoma were included in the study. Tumors were transplanted to an orthotopic site

SUBMITTER: Huang R 

PROVIDER: S-EPMC5634823 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature