Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo.

ABSTRACT:

Background

Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of craniofacial skeleton, dermis, pericytes, fat cells, and tenocytes; and - the mesoderm, which yields muscles, blood vessel endothelia and some posterior cranial bones. The molecular players that orchestrate co-development of cephalic NC and mesodermal cells to properly construct the head of vertebrates remain poorly understood. In this regard, Six1 gene, a vertebrate homolog of Drosophila Sine Oculis, is known to be required for development of ear, nose, tongue and cranial skeleton. However, the embryonic origin and fate of Six1-expressing

SUBMITTER: Fonseca BF 

PROVIDER: S-EPMC5634862 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature