Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study.

ABSTRACT:

Background & aims

Late-night dinner eating is associated with increased risk for type-2 diabetes. The underlying mechanism is unclear. One explanatory hypothesis is that the concurrence of elevated circulating melatonin and high glucose concentrations (characterizing late eating) leads to impaired glucose tolerance. However, to date no study has tested the influence of physiological melatonin concentrations on glucose-tolerance. The discovery of melatonin receptor MTNR1B as a diabetes risk gene provides evidence for a role of physiological levels of melatonin in glucose control. The aim of our study was to test the hypothesis that elevated endogenous melatonin concentrations worsen glucose control when eating late. Registered under ClinicalTrials.gov Identifier no. NCT03003936.

SUBMITTER: Lopez-Minguez J 

PROVIDER: S-EPMC5634913 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature