Evaluation of Metabolic Syndrome and Vitamin D Receptor Gene Polymorphism in Male Factor Infertility.

ABSTRACT: Male factor infertility (MFI) is a growing health issue in society. The vitamin D receptor gene (VDR) is expressed in many tissues and modulates expression of several other genes. The purpose of this study was to investigate the association between MetSyn, VDR gene (FokI, rs-2228570; C > T) polymorphisms and MFI in Indian adults. Fifty cases and fifty-four controls, fulfilling inclusion and exclusion criteria, were included with their informed consent. Fasting plasma glucose, triglyceride, HDL-C were estimated by clinical chemistry analyzer (Beckmam Coulter DXC 800, USA). Serum insulin was measured by electrochemiluminescence immunoassay and VDR gene polymorphism by RFLP-PCR. Statistical analysis was done using SPSS 20.0. MetSyn was more frequent in MFI cases than controls. There wa

SUBMITTER: Bhakat R 

PROVIDER: S-EPMC5634980 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature