Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles.

ABSTRACT: Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway. SFN may improve exercise endurance capacity by counteracting oxidative stress-induced damage during exercise. We assessed running ability based on an exhaustive treadmill test (progressive-continuous all-out) and examined the expression of markers for oxidative stress and muscle damage. Twelve- to 13-week-old Male wild-type mice (Nrf2 ^+/+) and Nrf2-null mice (Nrf2 ^-/-) on C57BL/6J background were intraperitoneally injected with SFN or vehicle prior to the test. The running distance of SFN-injected Nrf2 ^+/+ mice was significantly greater compared with that of uninjected mice. Enhanced running capac

SUBMITTER: Oh S 

PROVIDER: S-EPMC5635018 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature