The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis.

ABSTRACT: In intestinal epithelial cells (IEC), it was reported that the activation of the P2X7 receptor leads to the internalization of the glucose transporter GLUT2, which is accompanied by a reduction of IEC capacity to transport glucose. In this study, we used P2rx7 ^-/- mice to decipher P2X7 functions in intestinal glucose transport and to evaluate the impacts on metabolism. Immunohistochemistry analyses revealed the presence of GLUT2 at the apical domain of P2rx7 ^-/- jejunum enterocytes. Positron emission tomography and biodistribution studies demonstrated that glucose was more efficiently delivered to the circulation of knockout animals. These findings correlated with increase blood glucose, insulin, triglycerides and cholesterol levels. In fact, P2rx7 ^-/- mice

SUBMITTER: Arguin G 

PROVIDER: S-EPMC5635021 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature