S1P₁ deletion differentially affects TH17 and Regulatory T cells.

ABSTRACT: Sphingosine-1 phosphate receptor 1 (S1P₁) is critical for the egress of T and B cells out of lymphoid organs. Although S1P₁ agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P₁ signaling regulates Th17 and T_reg cell homeostasis. To study the impact of S1P₁ signaling on Th17 and T_reg cell biology, we specifically deleted S1P₁ in Th17 and T_reg cells using IL-17A ^Cre and Foxp3 ^Cre mice, respectively. Deletion of S1P₁ in Th17 cells conferred resistance to experimental autoimmune encephalomyelitis (EAE). On the other hand, permanent deletion of S1P₁ in T_reg cells resulted in autoimmunity and acute del

SUBMITTER: Eken A 

PROVIDER: S-EPMC5635040 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature