Early Changes in Alpha Band Power and DMN BOLD Activity in Alzheimer's Disease: A Simultaneous Resting State EEG-fMRI Study.

ABSTRACT: Simultaneous resting state functional magnetic resonance imaging (rsfMRI)-resting state electroencephalography (rsEEG) studies in healthy adults showed robust positive associations of signal power in the alpha band with BOLD signal in the thalamus, and more heterogeneous associations in cortical default mode network (DMN) regions. Negative associations were found in occipital regions. In Alzheimer's disease (AD), rsfMRI studies revealed a disruption of the DMN, while rsEEG studies consistently reported a reduced power within the alpha band. The present study is the first to employ simultaneous rsfMRI-rsEEG in an AD sample, investigating the association of alpha band power and BOLD signal, compared to healthy controls (HC). We hypothesized to find reduced positive associations in DMN region

SUBMITTER: Brueggen K 

PROVIDER: S-EPMC5635054 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature