MTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.

ABSTRACT: The mammalian target of rapamycin (mTOR)/regulatory-associated protein of mTOR (Raptor) pathway transmits and integrates different signals including growth factors, nutrients, and energy metabolism. Nearly all these signals have been found to play roles in skeletal biology. However, the contribution of mTOR/Raptor to osteoblast biology in vivo remains to be elucidated as the conclusions of recent studies are controversial. Here we report that mice with a deficiency of either mTOR or Raptor in preosteoblasts exhibited clavicular hypoplasia and delayed fontanelle fusion, similar to those found in human patients with cleidocranial dysplasia (CCD) haploinsufficient for the transcription factor runt-related transcription factor 2 (Runx2) or those identified in Runx2^+/- mice. Mechanis

SUBMITTER: Dai Q 

PROVIDER: S-EPMC5635215 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature