Anti-Alzheimer's Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

ABSTRACT: The family Polygonaceae is known for its traditional use in the management of various neurological disorders including Alzheimer's disease (AD). In search of new anti-AD drugs, β-sitosterol isolated from Polygonum hydropiper was subjected to in vitro, in vivo, behavioral and molecular docking studies to confirm its possibility as a potential anti-Alzheimer's agent. The in vitro AChE, BChE inhibitory potentials of β-sitosterol were investigated following Ellman's assay. The antioxidant activity was tested using DPPH, ABTS and H₂O₂ assays. Behavioral studies were performed on a sub-strain of transgenic mice using shallow water maze (SWM), Y-maze and balance beam tests. β-sitosterol was tested for in vivo inhibitory potentials against cholines

SUBMITTER: Ayaz M 

PROVIDER: S-EPMC5635809 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature