Ontology highlight
ABSTRACT:
SUBMITTER: Rao SS
PROVIDER: S-EPMC5635824 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cell 20141211 7
We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion contacts, achieving 1 kb resolution. We find that genomes are partitioned into contact domains (median length, 185 kb), which are associated with distinct patterns of histone marks and segregate into six subcompartments. We identify ∼10,000 loops. These loops frequently link promoters and enhancers, correlate with ...[more]