Microbial metabolites regulate host lipid metabolism through NR5A-Hedgehog signalling.

ABSTRACT: Microorganisms and their hosts share the same environment, and microbial metabolic molecules (metabolites) exert crucial effects on host physiology. Environmental factors not only shape the composition of the host's resident microorganisms, but also modulate their metabolism. However, the exact molecular relationship among the environment, microbial metabolites and host metabolism remains largely unknown. Here, we discovered that environmental methionine tunes bacterial methyl metabolism to regulate host mitochondrial dynamics and lipid metabolism in Caenorhabditis elegans through an endocrine crosstalk involving NR5A nuclear receptor and Hedgehog signalling. We discovered that methionine deficiency in bacterial medium decreases the production of bacterial metabolites that are essential fo

SUBMITTER: Lin CJ 

PROVIDER: S-EPMC5635834 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature