MIF and D-DT are potential disease severity modifiers in male MS subjects.

ABSTRACT: Little is known about mechanisms that drive the development of progressive multiple sclerosis (MS), although inflammatory factors, such as macrophage migration inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may contribute to disease worsening. Our findings demonstrate elevated MIF and D-DT levels in males with progressive disease compared with relapsing-remitting males (RRMS) and female MS subjects, with increased levels of CD74 in females vs. males with high MS disease severity. Furthermore, increased MIF and D-DT levels in males with progressive disease were significantly correlated with the presence of two high-expression promoter polymorphisms located in the MIF gene, a -794CATT_5-8 microsatellite repeat and a -173

SUBMITTER: Benedek G 

PROVIDER: S-EPMC5635923 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature