Genotype combination contributes to psoriasis: An exhaustive algorithm perspective.

ABSTRACT: Researchers have learned that nearly all conditions and diseases have a genetic component. With the benefit of technological advances, many single-nucleotide polymorphisms (SNPs) have been found to be associated with the risk of complex disorders by using genome wide association studies (GWASs). Disease-associated SNPs are sometimes shared by healthy controls and cannot clearly distinguish affected individuals from unaffected ones. The combined effects of multiple independent SNPs contribute to the disease process, but revealing the relationship between genotype and phenotype based on the combinations remains a great challenge. In this study, by considering the disease prevalence rate, we conducted an exhaustive process to identify whether a genotype combination pattern would have a decisi

SUBMITTER: Dou J 

PROVIDER: S-EPMC5636117 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature