Widespread epistasis regulates glucose homeostasis and gene expression.

ABSTRACT: The relative contributions of additive versus non-additive interactions in the regulation of complex traits remains controversial. This may be in part because large-scale epistasis has traditionally been difficult to detect in complex, multi-cellular organisms. We hypothesized that it would be easier to detect interactions using mouse chromosome substitution strains that simultaneously incorporate allelic variation in many genes on a controlled genetic background. Analyzing metabolic traits and gene expression levels in the offspring of a series of crosses between mouse chromosome substitution strains demonstrated that inter-chromosomal epistasis was a dominant feature of these complex traits. Epistasis typically accounted for a larger proportion of the heritable effects than those due sol

SUBMITTER: Chen A 

PROVIDER: S-EPMC5636166 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature