Association between ALDH₂ Glu504Lys polymorphism and colorectal cancer risk: a meta-analysis.

ABSTRACT:

Background

The findings from studies on the relationship between aldehyde dehydrogenases(ALDH) gene Glu504Lys polymorphism and colorectal cancer(CRC) were inconsistent.

Objectives

The aim of this meta-analysis was to assess ALDH gene Glu504Lys polymorphism and CRC risk.

Methods

All of the relevant studies were identified from PubMed and Embase database. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association. Nine studies with 2779 cases and 4533 controls were included.

Results

No significant variation in CRC risk was detected in any of the genetic models overall. To explore the sources of heterogeneity,we performed further sub-group analyses

SUBMITTER: Xinhua J 

PROVIDER: S-EPMC5636235 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature