Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): secondary outcomes of a multinational, randomised, double-blind, phase 3 trial.
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SUBMITTER: Coens C
PROVIDER: S-EPMC5636622 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Health-related quality of life with adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): secondary outcomes of a multinational, randomised, double-blind, phase 3 trial.
Coens Corneel C Suciu Stefan S Chiarion-Sileni Vanna V Grob Jean-Jacques JJ Dummer Reinhard R Wolchok Jedd D JD Schmidt Henrik H Hamid Omid O Robert Caroline C Ascierto Paolo A PA Richards Jon M JM Lebbé Celeste C Ferraresi Virginia V Smylie Michael M Weber Jeffrey S JS Maio Michele M Bottomley Andrew A Kotapati Srividya S de Pril Veerle V Testori Alessandro A Eggermont Alexander M M AMM
The Lancet. Oncology 20170203 3
<h4>Background</h4>The EORTC 18071 phase 3 trial compared adjuvant ipilimumab with placebo in patients with stage III melanoma. The primary endpoint, recurrence-free survival, was significantly longer in the ipilimumab group than in the placebo group. Investigator-reported toxic effects of ipilimumab consisted mainly of skin, gastrointestinal, endocrine, and hepatic immune-related adverse events. Adjuvant treatment with ipilimumab in this setting was approved in October, 2014, by the US Food and ...[more]
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