Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders.

ABSTRACT: Accumulating mental-health research encourages a shift in focus toward transdiagnostic dimensional features that are shared across categorical disorders. In support of this shift, recent studies have identified a general liability factor for psychopathology-sometimes called the 'p factor'- that underlies shared risk for a wide range of mental disorders. Identifying neural correlates of this general liability would substantiate its importance in characterizing the shared origins of mental disorders and help us begin to understand the mechanisms through which the 'p factor' contributes to risk. Here we believe we first replicate the 'p factor' using cross-sectional data from a volunteer sample of 1246 university students, and then using high-resolution multimodal structural neuroimaging, we

SUBMITTER: Romer AL 

PROVIDER: S-EPMC5636639 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature