INVOLVEMENT OF MULTIPLE MOLECULAR PATHWAYS IN THE GENETICS OF OCULAR REFRACTION AND MYOPIA.

ABSTRACT:

Purpose

The prevalence of myopia has increased dramatically worldwide within the last three decades. Recent studies have shown that refractive development is influenced by environmental, behavioral, and inherited factors. This review aims to analyze recent progress in the genetics of refractive error and myopia.

Methods

A comprehensive literature search of PubMed and OMIM was conducted to identify relevant articles in the genetics of refractive error.

Results

Genome-wide association and sequencing studies have increased our understanding of the genetics involved in refractive error. These studies have identified interesting candidate genes. All genetic loci discovered to date indicate that refractive development is a heterogeneous process mediated by a number of overl

SUBMITTER: Wojciechowski R 

PROVIDER: S-EPMC5636641 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature