Leukocyte telomere length, T cell composition and DNA methylation age.

ABSTRACT: Both leukocyte telomere length (LTL) and DNA methylation age are strongly associated with chronological age. One measure of DNA methylation age─ the extrinsic epigenetic age acceleration (EEAA)─ is highly predictive of all-cause mortality. We examined the relation between LTL and EEAA. LTL was measured by Southern blots and leukocyte DNA methylation was determined using Illumina Infinium HumanMethylation450 BeadChip in participants in the Women's Health Initiative (WHI; n=804), the Framingham Heart Study (FHS; n=909) and the Bogalusa Heart study (BHS; n=826). EEAA was computed using 71 DNA methylation sites, further weighted by proportions of naïve CD8⁺ T cells, memory CD8⁺ T cells, and plasmablasts. Shorter LTL was associated with increased EEAA in participants from

SUBMITTER: Chen BH 

PROVIDER: S-EPMC5636670 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature