Ontology highlight
ABSTRACT:
SUBMITTER: Cheekatla SS
PROVIDER: S-EPMC5636679 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cheekatla Satyanarayana Swamy SS Tripathi Deepak D Venkatasubramanian Sambasivan S Paidipally Padmaja P Welch Elwyn E Tvinnereim Amy R AR Nurieva Roza R Vankayalapati Ramakrishna R
Journal of immunology (Baltimore, Md. : 1950) 20170830 8
In this study, we determined the role of IL-21R signaling in <i>Mycobacterium tuberculosis</i> infection, using IL-21R knockout (KO) mice. A total of 50% of <i>M. tuberculosis</i> H37Rv<b>-</b>infected IL-21R KO mice died in 6 mo compared with no deaths in infected wild type (WT) mice. <i>M. tuberculosis</i><b>-</b>infected IL-21R KO mice had enhanced bacterial burden and reduced infiltration of Ag-specific T cells in lungs compared with <i>M. tuberculosis</i><b>-</b>infected WT mice. Ag-specifi ...[more]