LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide, with 500 000 new cases each year. However, the mechanisms underlying OSCC development are relatively unknown. In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was used to profile the differentially expressed peptides/proteins between OSCC tissues and their adjacent noncancerous tissues. Sixty-seven unique peptide peaks and five distinct proteins were identified with changed expression levels. Among them, LRP6 expression was found to be upregulated in OSCC tissues, and correlated with a cluster of clinicopathologic parameters, including smoking, drinking, tumor differentiation status, lymph node metastasis and survival time. Nota

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC5636978 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature