The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system.

ABSTRACT: The 'classical' renin-angiotensin system (RAS) is a circulating system that controls blood pressure. Local/paracrine RAS, identified in a variety of tissues, including the brain, is involved in different functions and diseases, and RAS blockers are commonly used in clinical practice. A third type of RAS (intracellular/intracrine RAS) has been observed in some types of cells, including neurons. However, its role is still unknown. The present results indicate that in brain cells the intracellular RAS counteracts the intracellular superoxide/H₂O₂ and oxidative stress induced by the extracellular/paracrine angiotensin II acting on plasma membrane receptors. Activation of nuclear receptors by intracellular or internalized angiotensin triggers a number of mechanisms that pr

SUBMITTER: Villar-Cheda B 

PROVIDER: S-EPMC5636983 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature