G allele at -924 A > G position of FoxP3 gene promoter as a risk factor for tuberculosis.

ABSTRACT:

Background

Forkhead box protein 3 (FoxP3) is an important factor for development and function of Regulatory T cells (Treg). Studies have found an association between common gene polymorphisms in FoxP3 and some infectious diseases. The aim of this study was to evaluate possible associations between two Single nucleotide polymorphisms (SNPs) in the promoter of the FoxP3 gene to susceptibility to tuberculosis (TB) and the alteration of Foxp3 gene expression.

Methods

The pattern distribution of genotype at two position, -3279 A > C (rs3761548) and -924 A > G (rs2232365) on the promoter of FoxP3 gene was evaluated using polymerase chain reaction-single specific primer (PCR-SSP) method in 183 tuberculosis patients and 183 healthy control. In addition the quantity of FoxP3 gene exp

SUBMITTER: Beiranvand E 

PROVIDER: S-EPMC5637085 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature