Ontology highlight
ABSTRACT:
SUBMITTER: Mossine AV
PROVIDER: S-EPMC5637095 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Bioconjugate chemistry 20160414 5
Three new positron emission tomography (PET) radiotracers of interest to our functional neuroimaging and translational oncology programs have been prepared through new developments in [(11)C]CO2 fixation chemistry. [(11)C]QZ (glutaminyl cyclase) was prepared via a tandem trapping of [(11)C]CO2/intramolecular cyclization; [(11)C]tideglusib (glycogen synthase kinase-3) was synthesized through a tandem trapping of [(11)C]CO2 followed by an intermolecular cycloaddition between a [(11)C]isocyanate an ...[more]