Willingness to participate in pragmatic dialysis trials: the importance of physician decisional autonomy and consent approach.

ABSTRACT:

Background

Pragmatic clinical trials embedded in routine delivery of clinical care can lead to improvements in quality of care, but often have design features that raise ethical concerns.

Methods

We performed a discrete choice experiment and used conjoint analysis to assess how specific attributes of pragmatic dialysis trials influenced patients' and physicians' willingness to have their dialysis facility participate in a hypothetical trial of hypertension management. Electronic survey data were collected from 200 patients enrolled from 11 outpatient hemodialysis units and from 203 nephrologists. The three attributes studied were physicians' treatment autonomy, participants' research burden, and the approach to consent. The influence of each attribute was quantified using mi

SUBMITTER: Courtright KR 

PROVIDER: S-EPMC5637128 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature