A Bacterial Stress Response Regulates Respiratory Protein Complexes To Control Envelope Stress Adaptation.

ABSTRACT: The Cpx envelope stress response mediates adaptation to stresses that affect protein folding within the envelope of Gram-negative bacteria. Recent transcriptome analyses revealed that the Cpx response impacts genes that affect multiple cellular functions predominantly associated with the cytoplasmic membrane. In this study, we examined the connection between the Cpx response and the respiratory complexes NADH dehydrogenase I and cytochrome bo3 in enteropathogenic Escherichia coli We found that the Cpx response directly represses the transcription of the nuo and cyo operons and that Cpx-mediated repression of these complexes confers adaptation to stresses that compromise envelope integrity. Furthermore, we found that the activity of the aerobic electron transport chain is reduced in E. coli

SUBMITTER: Guest RL 

PROVIDER: S-EPMC5637174 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature