Ontology highlight
ABSTRACT:
SUBMITTER: Mackay A
PROVIDER: S-EPMC5637314 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20170928 4
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grad ...[more]