Ontology highlight
ABSTRACT:
SUBMITTER: Klein Geltink RI
PROVIDER: S-EPMC5637396 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Cell 20170914 2
T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an enzyme that facilitates mitochondrial fatty acid oxidation (FAO), before the first cell division, coinciding with mitochondrial elongation and enhanced spare respiratory capacity (SR ...[more]