Protein-Specific Differential Glycosylation of Immunoglobulins in Serum of Ovarian Cancer Patients.

ABSTRACT: Previous studies indicated that glycans in serum may serve as biomarkers for diagnosis of ovarian cancer; however, it was unclear to which proteins these glycans belong. We hypothesize that protein-specific glycosylation profiles of the glycans may be more informative of ovarian cancer and can provide insight into biological mechanisms underlying glycan aberration in serum of diseased individuals. Serum samples from women diagnosed with epithelial ovarian cancer (EOC, n = 84) and matched healthy controls (n = 84) were obtained from the Gynecologic Oncology Group. Immunoglobulin (IgG, IgA, and IgM) concentrations and glycosylation profiles were quantified using multiple reaction monitoring mass spectrometry. Differential and classification analyses were performed to identify aberrant protei

SUBMITTER: Ruhaak LR 

PROVIDER: S-EPMC5637400 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature