Histamine-2 receptor antagonist famotidine modulates cardiac stem cell characteristics in hypertensive heart disease.

ABSTRACT:

Background

Cardiac stem cells (CSCs) play a vital role in cardiac homeostasis. A decrease in the efficiency of cardiac stem cells is speculated in various cardiac abnormalities. The maintenance of a healthy stem cell population is essential for the prevention of adverse cardiac remodeling leading to cardiac failure. Famotidine, a histamine-2 receptor antagonist, is currently used to treat ulcers of the stomach and intestines. In repurposing the use of the drug, reduction of cardiac hypertrophy and improvement in cardiac function of spontaneously hypertensive rats (SHR) was reported by our group. Given that stem cells are affected in cardiac pathologies, the effect of histamine-2 receptor antagonism on CSC characteristics was investigated.

Methods

To examine whether famotidin

SUBMITTER: Saheera S 

PROVIDER: S-EPMC5637875 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature