Maternal hyperglycemia in singleton pregnancies conceived by IVF may be modified by first-trimester BMI.

ABSTRACT:

Study question

Does IVF independently increase the risk of gestational diabetes mellitus (GDM) and is this increase in risk modified by maternal body mass index?

Summary answer

IVF appears to be an independent risk factor for GDM and elevated blood glucose levels in overweight women (BMI > 25 kg/m2).

What is known already

IVF has been associated with increased risk of GDM, but most previous studies did not adequately assess confounding or effect modification by other risk factors.

Study design, size, duration

Cross-sectional study using data from 1089 women with singleton pregnancies who participated in a Singaporean birth cohort study (GUSTO) and received a 75 g oral glucose tolerance test (OGTT) at 26-28 weeks gestation.

Participants/materials, setting, me

SUBMITTER: Cai S 

PROVIDER: S-EPMC5638004 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature