Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.

ABSTRACT: We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action (t _max,IA ) and insulin sensitivity ( S _I ) during both interventions, and correlated these with demographic factors and glycaemic outcomes. During both interventions, t _max,IA was positively correlated with pre- and post-intervention HbA1c (r = 0.50-0.52, P  < .01) and mean glucose (r = 0.45-0.62, P  < .05), and inve

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC5638091 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature