Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders.

ABSTRACT: Emotion recognition is disrupted in many mental health disorders, which may reflect shared genetic aetiology between this trait and these disorders. We explored genetic influences on emotion recognition and the relationship between these influences and mental health phenotypes. Eight-year-old participants (n = 4,097) from the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Diagnostic Analysis of Non-Verbal Accuracy (DANVA) faces test. Genome-wide genotype data was available from the Illumina HumanHap550 Quad microarray. Genome-wide association studies were performed to assess associations with recognition of individual emotions and emotion in general. Exploratory polygenic risk scoring was performed using published genomic data for schizophrenia, bipolar disorder, de

SUBMITTER: Coleman JRI 

PROVIDER: S-EPMC5638097 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature