Ultra-high-field magnetic resonance spectroscopy in non-alcoholic fatty liver disease: Novel mechanistic and diagnostic insights of energy metabolism in non-alcoholic steatohepatitis and advanced fibrosis.

ABSTRACT:

Background & aims

With the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) non-invasive tools obtaining pathomechanistic insights to improve risk stratification are urgently needed. We therefore explored high- and ultra-high-field magnetic resonance spectroscopy (MRS) to obtain novel mechanistic and diagnostic insights into alterations of hepatic lipid, cell membrane and energy metabolism across the spectrum of NAFLD.

Methods

MRS and liver biopsy were performed in 30 NAFLD patients with NAFL (n=8) or NASH (n=22). Hepatic lipid content and composition were measured using 3-Tesla proton (¹ H)-MRS. 7-Tesla phosphorus (³¹ P)-MRS was applied to determine phosphomonoester (PME) including phosphoethanolamine (PE), phos

SUBMITTER: Traussnigg S 

PROVIDER: S-EPMC5638103 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature