Role of p16 testing in cervical cancer screening among HIV-infected women.

ABSTRACT:

Background

p16 immunohistochemistry is used to evaluate for HPV-associated cervical intraepithelial neoplasia. The diagnostic performance of p16 in HIV infection is unclear.

Methods

Between June-December 2009, HIV-infected women underwent Papanicolaou (Pap) smear, human papillomavirus (HPV) testing, visual inspection with acetic acid (VIA), and colposcopy-directed biopsy as the disease gold standard at a HIV clinic in Kenya. Pap smears were evaluated for p16 expression. Sensitivity, specificity, positive predictive value (PPV), and area under the receiver operating characteristic curve (AUC) of p16 to detect CIN2/3 on histology and the impact of immunosuppression and ART was assessed.

Results

Of 331 cervical samples with p16 expression, p16 sensitivity and specificity

SUBMITTER: McGrath CJ 

PROVIDER: S-EPMC5638250 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature