PICKLE 2.0: A human protein-protein interaction meta-database employing data integration via genetic information ontology.

ABSTRACT: It has been acknowledged that source databases recording experimentally supported human protein-protein interactions (PPIs) exhibit limited overlap. Thus, the reconstruction of a comprehensive PPI network requires appropriate integration of multiple heterogeneous primary datasets, presenting the PPIs at various genetic reference levels. Existing PPI meta-databases perform integration via normalization; namely, PPIs are merged after converted to a certain target level. Hence, the node set of the integrated network depends each time on the number and type of the combined datasets. Moreover, the irreversible a priori normalization process hinders the identification of normalization artifacts in the integrated network, which originate from the nonlinearity characterizing the genetic informatio

SUBMITTER: Gioutlakis A 

PROVIDER: S-EPMC5638325 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature