A theoretical framework for analyzing coupled neuronal networks: Application to the olfactory system.

ABSTRACT: Determining how synaptic coupling within and between regions is modulated during sensory processing is an important topic in neuroscience. Electrophysiological recordings provide detailed information about neural spiking but have traditionally been confined to a particular region or layer of cortex. Here we develop new theoretical methods to study interactions between and within two brain regions, based on experimental measurements of spiking activity simultaneously recorded from the two regions. By systematically comparing experimentally-obtained spiking statistics to (efficiently computed) model spike rate statistics, we identify regions in model parameter space that are consistent with the experimental data. We apply our new technique to dual micro-electrode array in vivo recordings fro

SUBMITTER: Barreiro AK 

PROVIDER: S-EPMC5638622 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature