HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription.

ABSTRACT: Abnormal differentiation of muscle is closely associated with aging (sarcopenia) and diseases such as cancer and type II diabetes. Thus, understanding the mechanisms that regulate muscle differentiation will be useful in the treatment and prevention of these conditions. Protein lysine acetylation and methylation are major post-translational modification mechanisms that regulate key cellular processes. In this study, to elucidate the relationship between myogenic differentiation and protein lysine acetylation/methylation, we performed a PCR array of enzymes related to protein lysine acetylation/methylation during C2C12 myoblast differentiation. Our results indicated that the expression pattern of HDAC11 was substantially increased during myoblast differentiation. Furthermore, ectopic expres

SUBMITTER: Byun SK 

PROVIDER: S-EPMC5638774 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature